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الريفامبين، وبعض أدوية علاج الصرع، مثل الكارباميزابين والفينيتوين؛ حيث يؤدي الاستعمال المتزامن إلى خفض مستويات التادالافيل في الدم وبالتالي التقليل من فعاليته.
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يصف الأطباء سياليس للحد من أعراض تضخم البروستاتا الحميد المتمثلة في ضعف تدفق البول، أو عدم القدرة على الإفراغ الكامل، والألم عند التبول.